Convenient Indole Synthesis from 2-Iodoanilines and Terminal Alkynes by the Sequential Sonogashira Reaction and the Cyclization Reaction Promoted by Tetrabutylammonium Fluoride (TBAF)

The sequential Sonogashira reaction and the cyclization reaction of various 2-iodoanilines and terminal alkynes in the presence of a palladium catalyst and tetrabutylammonium fluoride (TBAF) gave the corresponding 2-substituted indoles in good yields.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2003, Vol.51(10), pp.1170-1173
Hauptverfasser:	Suzuki, Naoyuki, Yasaki, Sakura, Yasuhara, Akito, Sakamoto, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	2-ethynylaniline Alkynes - chemical synthesis Aniline Compounds - chemical synthesis Chemistry Cyclization Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives indole Indoles - chemical synthesis Organic chemistry palladium-catalyzed reaction Preparations and properties Quaternary Ammonium Compounds - chemistry sequential cyclization terminal alkyne tetrabutylammnonium fluoride
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Beschreibung
Zusammenfassung:	The sequential Sonogashira reaction and the cyclization reaction of various 2-iodoanilines and terminal alkynes in the presence of a palladium catalyst and tetrabutylammonium fluoride (TBAF) gave the corresponding 2-substituted indoles in good yields.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.51.1170