Sequiterpenoid Derivatives from Ferula ferulioides. III

Three new prenyl-benzoylfuranone type sesquiterpenoid derivatives, 3S*-(2, 4-dihydroxybenzoyl)-4R*, 5R*-dimethyl-5-(4, 8-dimethyl-3(E), 7(E)-nonadien-1-yl)tetrahydro-2-furanone, 3S*-(2, 4-dihydroxybenzoyl)-4R*, 5R*-dimethyl-5-[4-methyl-5-(4-methyl-2-furyl)-3(E)-penten-1-yl]tetrahydro-2-furanone and 3S*-(2, 4-dihydroxybenzoyl)-4R*, 5R*-dimethyl-5-[4-methyl-5-(4-methyl-2-furyl)-3(E)-penten-1-yl]tetrahydro-2-furanone were isolated from the roots of Ferula ferulioides. The structures were established by comprehensive spectral analysis. The biosynthetic pathway leading to their prenyl-benzoylfuranone type sesquiterpenoids is proposed based on their structures.