THE CHIRAL LIGAND-CATALYZED ENANTIOSELECTIVE CONJUGATE ADDITION OF ORGANOLITHIUM TO BHA ENOATE

THE CHIRAL LIGAND-CATALYZED ENANTIOSELECTIVE CONJUGATE ADDITION OF ORGANOLITHIUM TO BHA ENOATE

The conjugate addition reaction of BHA alkenoates with butyl- and phenyllithiums in toluene at -78°C were catalyzed by a substoichiometric amount of chiral ligands 1 and 2 to give the corresponding 3-substituted alkanoates in good to modest ees.

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1998/01/15, Vol.46(1), pp.184-186
Hauptverfasser: ASANO, Yasutomi, IIDA, Akira, TOMIOKA, Kiyoshi
Format: Artikel
Sprache:eng
Schlagworte:
addition
Aliphatic compounds
catalyst
Chemistry
chiral ligand
Exact sciences and technology
Organic chemistry
organolithium
Preparations and properties
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Beschreibung
Zusammenfassung:The conjugate addition reaction of BHA alkenoates with butyl- and phenyllithiums in toluene at -78°C were catalyzed by a substoichiometric amount of chiral ligands 1 and 2 to give the corresponding 3-substituted alkanoates in good to modest ees.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.46.184