Lipase-Catalyzed Resolution of Sterically Crowded 1, 2-Diols

Lipase-Catalyzed Resolution of Sterically Crowded 1, 2-Diols

An enzymatic method for preparation of the enantiomers of chiral diols 2a, b and their monoacetates 3a, b with 100% enantiomeric purity by using lipase-catalyzed esterification and/or hydrolysis was established, The (R)-enantiomers were more reactive in both acetylation of (±)-2a, b and hydrolysis o...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1995/10/15, Vol.43(10), pp.1659-1662
Hauptverfasser: KHLEBNIKOV, Vladimir, MORI, Kenji, TERASHIMA, Kohji, TANAKA, Yuji, SATO, Makoto
Format: Artikel
Sprache:eng
Schlagworte:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
enzymatic resolution
Fundamental and applied biological sciences. Psychology
lipase
Methods. Procedures. Technologies
vicinal diol
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Zusammenfassung:An enzymatic method for preparation of the enantiomers of chiral diols 2a, b and their monoacetates 3a, b with 100% enantiomeric purity by using lipase-catalyzed esterification and/or hydrolysis was established, The (R)-enantiomers were more reactive in both acetylation of (±)-2a, b and hydrolysis of (±)-3a, b catalyzed by lipase OF-360 from Candida cylindracea.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.43.1659