TOTAL SYNTHESIS OF NATURAL(+)-DUOCARMYCIN SA

A total synthesis of natural (+)-duocarmycin SA (1) was achieved as shown in Chart 1, starting from L-malic acid (5) by using a Lewis acid-mediated indole formation reaction of a pyrrole precursor 14 to form the key compound 15.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1995/06/15, Vol.43(6), pp.1064-1066
Hauptverfasser:	MURATAKE, Hideaki, MATSUMURA, Naoshige, NATSUME, Mitsutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	antitumor antibiotic Chemistry duocarmycin SA Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings indole formation reaction Organic chemistry Preparations and properties total synthesis
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Beschreibung
Zusammenfassung:	A total synthesis of natural (+)-duocarmycin SA (1) was achieved as shown in Chart 1, starting from L-malic acid (5) by using a Lewis acid-mediated indole formation reaction of a pyrrole precursor 14 to form the key compound 15.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.43.1064