ENANTIO- AND DIASTEREOCONTROLLED SYNTHESIS OF EPIBATIDINE ANALOGUES

ENANTIO- AND DIASTEREOCONTROLLED SYNTHESIS OF EPIBATIDINE ANALOGUES

Three structural analogus of a potent non-opiate analgesic alkaloid epibatidine have been synthesized in optically pure forms in enantio- and diastereo-controlled ways using a chiral 2, 5-cyclohexadiene-1, 4-diol synthon.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical & pharmaceutical bulletin 1995/05/15, Vol.43(5), pp.901-903
Hauptverfasser: HIROYA, Kou, UWAI, Koji, OGASAWARA, Kunio
Format: Artikel
Sprache:eng
Schlagworte:
7-azabicyclo[2.2.1]heptane
Chemistry
enantiocontrolled synthesis
epibatidine
epibatidine analogue
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Organic chemistry
Preparations and properties
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Beschreibung
Zusammenfassung:Three structural analogus of a potent non-opiate analgesic alkaloid epibatidine have been synthesized in optically pure forms in enantio- and diastereo-controlled ways using a chiral 2, 5-cyclohexadiene-1, 4-diol synthon.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.43.901