Preparation of 2, 2-Disubstituted 2, 3-Dihydro-3-phenyl-1, 3, 4-thiadiazoles

Preparation of 2, 2-Disubstituted 2, 3-Dihydro-3-phenyl-1, 3, 4-thiadiazoles

Reaction of N'-phenylthioformohydrazide with ketones in the presence of trimethylsilyl chloride proceeded easily to afford the corresponding 2, 2-disubstituted 2, 3-dihydro-3-phenyl-1, 3, 4-thiadiazoles in good yields.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical & pharmaceutical bulletin 1994/09/15, Vol.42(9), pp.1912-1913
Hauptverfasser: KITANO, Kazutada, MATSUBARA, Yoshio, YOSHIHARA, Masakuni, MAESHIMA, Toshihisa
Format: Artikel
Sprache:eng
Schlagworte:
2, 3-dihydro-3-phenyl-1, 3, 4-thiadiazole
Chemistry
cyclization
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
ketone
Organic chemistry
Preparations and properties
trimethylsilyl chloride
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Beschreibung
Zusammenfassung:Reaction of N'-phenylthioformohydrazide with ketones in the presence of trimethylsilyl chloride proceeded easily to afford the corresponding 2, 2-disubstituted 2, 3-dihydro-3-phenyl-1, 3, 4-thiadiazoles in good yields.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.42.1912