Absolute Structure of 2'-Desacetoxyaustrospicatine Established by X-Ray analysis and Circular Dichroism Spectroscopy

Three taxane diterpenes, taxinine (1), taxinine B (2), and 2'-desacetoxyaustrospicatin (3), have been isolated from Taxus cuspidata SIEB et ZUCC. The absolute stereostructure of 3 has been determined by a combination of X-ray analysis and circular dichroism (CD) spectroscopy. Complete assignmen...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1994/12/15, Vol.42(12), pp.2621-2624
Hauptverfasser:	KONDA, Yaeko, SASAKI, Tomomitsu, SUN, Xue-Long, LI, Xian, ONDA, Masayuki, TAKAYANAGI, Hiroaki, HARIGAYA, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	2'-desacetoxyaustrospicatin absolute structure Biological and medical sciences Biological compounds CD spectruym Condensed matter: structure, mechanical and thermal properties Exact sciences and technology General pharmacology Medical sciences Organic compounds Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Physics Structure of solids and liquids crystallography Structure of specific crystalline solids taxane diterpene X-ray analysis
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Zusammenfassung:	Three taxane diterpenes, taxinine (1), taxinine B (2), and 2'-desacetoxyaustrospicatin (3), have been isolated from Taxus cuspidata SIEB et ZUCC. The absolute stereostructure of 3 has been determined by a combination of X-ray analysis and circular dichroism (CD) spectroscopy. Complete assignments of 1H- and 13C-nuclear magnetic resonance (NMR) signals for 1 and 2 have been made on the basis of two-dimensional (2D) NMR techniques.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.42.2621