A New Synthetic Route to 1, 5-Benzothiazepines. Synthesis of Derivatives of Diltiazem

Several derivatives of diltiazem (9a-c) have been synthesized from the oxamate (6) through the carbon-carbon ring closure of the sulfur-stabilized benzylic anion and the ester carbonyl group, followed by stereoselective reduction of the C3-carbonyl of the 1, 5-benzothiazepine-dione (7).

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1992/08/25, Vol.40(8), pp.1986-1989
Hauptverfasser:	HARADA, Tsunehiro, MORIMOTO, Masamichi, NAGASAWA, Masaaki, TAKAMURA, norio, INOUE, Hirozumi, OH-ISHI, Tokuro, TAKEDA, Mikio
Format:	Artikel
Sprache:	eng
Schlagworte:	1, 5-benzothiazepine calcium antagonist Chemistry diltiazem derivative Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Organic chemistry Preparations and properties ring closure synthesis
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Beschreibung
Zusammenfassung:	Several derivatives of diltiazem (9a-c) have been synthesized from the oxamate (6) through the carbon-carbon ring closure of the sulfur-stabilized benzylic anion and the ester carbonyl group, followed by stereoselective reduction of the C3-carbonyl of the 1, 5-benzothiazepine-dione (7).
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.40.1986