Development of a Highly Cardioselective Ultra Short-Acting [beta]-Blocker, ONO-1101

Development of a Highly Cardioselective Ultra Short-Acting [beta]-Blocker, ONO-1101

A novel, highly cardioselective ultra short-acting β-blocker, ONO-1101, has been developed for application in the emergency treatment of tachycardia and better control of heart rate in surgery. This agent is approximately nine times more potent in β-blocking activity in vivo and eight times more car...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1992-06, Vol.40 (6), p.1462
Hauptverfasser: IGUCHI, Sadahiko, IWAMURA, Hiroyuki, NISHIZAKI, Minoru, HAYASHI, Akio, SENOKUCHI, Kazuhiko, KOBAYASHI, Kaoru, SAKAKI, Katsuhito, HACHIYA, Katsutoshi, ICHIOKA, Yumiko, KAWAMURA, Masanori
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Sprache:eng
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Zusammenfassung:A novel, highly cardioselective ultra short-acting β-blocker, ONO-1101, has been developed for application in the emergency treatment of tachycardia and better control of heart rate in surgery. This agent is approximately nine times more potent in β-blocking activity in vivo and eight times more cardioselective in vitro than esmolol. This β-blocking drug has a short duration of activity, enabling rapid recovery after cessation of administration if side effects occur. It can be used safely in patients suffering from acute heart disease and represents a major therapeutic advance in the treatment of heart disease.
ISSN:0009-2363
1347-5223