Water Mobility in Aqueous Solutions of Macromolecular Pharmaceutical Excipients Measured by Oxygen-17 Nuclear Magnetic Resonance

The dynamics of water molecules associated with water-soluble polymers were studied by 17O-NMR. The observed spin-lattice relaxation time, T1(obs), of water in aqueous solutions of polyethylene glycol (PEG), poly(vinylpyrrolidone) (PVP) and gelatin at polymer concentrations below 0.12 g/g of water c...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical & pharmaceutical bulletin 1995/07/15, Vol.43(7), pp.1221-1223
Hauptverfasser:	OTSUKA, Tomoko, YOSHIOKA, Sumie, ASO, Yukio, KOJIMA, Shigeo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences gelatin General pharmacology Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments poly(vinylpyrrolidone) polyethyleneglycol spin-lattice relaxation time water mobility
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!