Water Mobility in Aqueous Solutions of Macromolecular Pharmaceutical Excipients Measured by Oxygen-17 Nuclear Magnetic Resonance

The dynamics of water molecules associated with water-soluble polymers were studied by 17O-NMR. The observed spin-lattice relaxation time, T1(obs), of water in aqueous solutions of polyethylene glycol (PEG), poly(vinylpyrrolidone) (PVP) and gelatin at polymer concentrations below 0.12 g/g of water c...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1995/07/15, Vol.43(7), pp.1221-1223
Hauptverfasser:	OTSUKA, Tomoko, YOSHIOKA, Sumie, ASO, Yukio, KOJIMA, Shigeo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences gelatin General pharmacology Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments poly(vinylpyrrolidone) polyethyleneglycol spin-lattice relaxation time water mobility
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Beschreibung
Zusammenfassung:	The dynamics of water molecules associated with water-soluble polymers were studied by 17O-NMR. The observed spin-lattice relaxation time, T1(obs), of water in aqueous solutions of polyethylene glycol (PEG), poly(vinylpyrrolidone) (PVP) and gelatin at polymer concentrations below 0.12 g/g of water could be described by an isotropic two-state model with a fast exchange. The tendency for the polymers to reduce the T1(obs) of water was on the oreder of PEG
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.43.1221