Water Mobility in Aqueous Solutions of Macromolecular Pharmaceutical Excipients Measured by Oxygen-17 Nuclear Magnetic Resonance
The dynamics of water molecules associated with water-soluble polymers were studied by 17O-NMR. The observed spin-lattice relaxation time, T1(obs), of water in aqueous solutions of polyethylene glycol (PEG), poly(vinylpyrrolidone) (PVP) and gelatin at polymer concentrations below 0.12 g/g of water c...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1995/07/15, Vol.43(7), pp.1221-1223 |
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| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 43 |
| creator | OTSUKA, Tomoko YOSHIOKA, Sumie ASO, Yukio KOJIMA, Shigeo |
| description | The dynamics of water molecules associated with water-soluble polymers were studied by 17O-NMR. The observed spin-lattice relaxation time, T1(obs), of water in aqueous solutions of polyethylene glycol (PEG), poly(vinylpyrrolidone) (PVP) and gelatin at polymer concentrations below 0.12 g/g of water could be described by an isotropic two-state model with a fast exchange. The tendency for the polymers to reduce the T1(obs) of water was on the oreder of PEG |
| doi_str_mv | 10.1248/cpb.43.1221 |
| format | Article |
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The observed spin-lattice relaxation time, T1(obs), of water in aqueous solutions of polyethylene glycol (PEG), poly(vinylpyrrolidone) (PVP) and gelatin at polymer concentrations below 0.12 g/g of water could be described by an isotropic two-state model with a fast exchange. The tendency for the polymers to reduce the T1(obs) of water was on the oreder of PEG<gelatin<PVP. At higher concentrations, deviations from the model were observed for PVP and gelatin. The T1(obs) of water in the PEG solution was not affected by the molecular weight of the polymer. This suggests that the microviscosity around the polymer molecules is governed by the interaction between the polymer unit and water molecules, and is not affected by the molecular weight of polymers in contrast to the "macroviscosity". The polymer-water interaction that reduced the T1(obs) of water was found to decrease with increasing temperature for all the polymers studied. The T1(obs) of water in the gelatin solution exhibited the largest temperature dependence, suggesting that changes might occur in the molecular structure of gelatin at higher temperatures.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.43.1221</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Biological and medical sciences ; gelatin ; General pharmacology ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; poly(vinylpyrrolidone) ; polyethyleneglycol ; spin-lattice relaxation time ; water mobility</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1995/07/15, Vol.43(7), pp.1221-1223</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1995 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4971-3de478b81342e29ea21f31e171b97e22aceb493902cffbfd0817efc14f7a9eb43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3645780$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>OTSUKA, Tomoko</creatorcontrib><creatorcontrib>YOSHIOKA, Sumie</creatorcontrib><creatorcontrib>ASO, Yukio</creatorcontrib><creatorcontrib>KOJIMA, Shigeo</creatorcontrib><title>Water Mobility in Aqueous Solutions of Macromolecular Pharmaceutical Excipients Measured by Oxygen-17 Nuclear Magnetic Resonance</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>The dynamics of water molecules associated with water-soluble polymers were studied by 17O-NMR. The observed spin-lattice relaxation time, T1(obs), of water in aqueous solutions of polyethylene glycol (PEG), poly(vinylpyrrolidone) (PVP) and gelatin at polymer concentrations below 0.12 g/g of water could be described by an isotropic two-state model with a fast exchange. The tendency for the polymers to reduce the T1(obs) of water was on the oreder of PEG<gelatin<PVP. At higher concentrations, deviations from the model were observed for PVP and gelatin. The T1(obs) of water in the PEG solution was not affected by the molecular weight of the polymer. This suggests that the microviscosity around the polymer molecules is governed by the interaction between the polymer unit and water molecules, and is not affected by the molecular weight of polymers in contrast to the "macroviscosity". The polymer-water interaction that reduced the T1(obs) of water was found to decrease with increasing temperature for all the polymers studied. The T1(obs) of water in the gelatin solution exhibited the largest temperature dependence, suggesting that changes might occur in the molecular structure of gelatin at higher temperatures.</description><subject>Biological and medical sciences</subject><subject>gelatin</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>poly(vinylpyrrolidone)</subject><subject>polyethyleneglycol</subject><subject>spin-lattice relaxation time</subject><subject>water mobility</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNpFkEtrGzEUhUVpoG7SVf-AoN2VSfQaa2Zp0rzATkKa0KXQyFfumLHkSjNg7_LTcwcHZyMJznfP1TmEfOfsnAtVXbhtc64kvgX_RCZcKl2UQsjPZMIYqwshp_IL-ZrzmjFRMi0n5PWv7SHRRWzaru33tA109n-AOGT6J3ZD38aQafR0YV2Km9iBGzqb6OM_mzbWAQLOdvRq59ptC6HPdAE2DwmWtNnTh91-BaHgmt4PrgOcW9hVAJyhT5BjsMHBGTnxtsvw7f0-JS_XV8-Xt8X84ebucjYvnKo1L-QSlK6aCjMJEDVYwb3kwDVvag1C4F8aVcuaCed945es4hq848prW6MkT8mPg-82RQyYe7OOQwq40nA1ZWJa8qpC6teBwrQ5J_Bmm9qNTXvDmRkrNlixUdKMFSP9893TZqzBJwzU5uOInKpSVwyx3wdsnXu7gqNuEzbRwWjJ67IabfXhGN0_ZOzaQJBvj5OVSA</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>OTSUKA, Tomoko</creator><creator>YOSHIOKA, Sumie</creator><creator>ASO, Yukio</creator><creator>KOJIMA, Shigeo</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>1995</creationdate><title>Water Mobility in Aqueous Solutions of Macromolecular Pharmaceutical Excipients Measured by Oxygen-17 Nuclear Magnetic Resonance</title><author>OTSUKA, Tomoko ; YOSHIOKA, Sumie ; ASO, Yukio ; KOJIMA, Shigeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4971-3de478b81342e29ea21f31e171b97e22aceb493902cffbfd0817efc14f7a9eb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Biological and medical sciences</topic><topic>gelatin</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>poly(vinylpyrrolidone)</topic><topic>polyethyleneglycol</topic><topic>spin-lattice relaxation time</topic><topic>water mobility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OTSUKA, Tomoko</creatorcontrib><creatorcontrib>YOSHIOKA, Sumie</creatorcontrib><creatorcontrib>ASO, Yukio</creatorcontrib><creatorcontrib>KOJIMA, Shigeo</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OTSUKA, Tomoko</au><au>YOSHIOKA, Sumie</au><au>ASO, Yukio</au><au>KOJIMA, Shigeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Water Mobility in Aqueous Solutions of Macromolecular Pharmaceutical Excipients Measured by Oxygen-17 Nuclear Magnetic Resonance</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1995</date><risdate>1995</risdate><volume>43</volume><issue>7</issue><spage>1221</spage><epage>1223</epage><pages>1221-1223</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>The dynamics of water molecules associated with water-soluble polymers were studied by 17O-NMR. The observed spin-lattice relaxation time, T1(obs), of water in aqueous solutions of polyethylene glycol (PEG), poly(vinylpyrrolidone) (PVP) and gelatin at polymer concentrations below 0.12 g/g of water could be described by an isotropic two-state model with a fast exchange. The tendency for the polymers to reduce the T1(obs) of water was on the oreder of PEG<gelatin<PVP. At higher concentrations, deviations from the model were observed for PVP and gelatin. The T1(obs) of water in the PEG solution was not affected by the molecular weight of the polymer. This suggests that the microviscosity around the polymer molecules is governed by the interaction between the polymer unit and water molecules, and is not affected by the molecular weight of polymers in contrast to the "macroviscosity". The polymer-water interaction that reduced the T1(obs) of water was found to decrease with increasing temperature for all the polymers studied. The T1(obs) of water in the gelatin solution exhibited the largest temperature dependence, suggesting that changes might occur in the molecular structure of gelatin at higher temperatures.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><doi>10.1248/cpb.43.1221</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 1995/07/15, Vol.43(7), pp.1221-1223 |
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| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Biological and medical sciences gelatin General pharmacology Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments poly(vinylpyrrolidone) polyethyleneglycol spin-lattice relaxation time water mobility |
| title | Water Mobility in Aqueous Solutions of Macromolecular Pharmaceutical Excipients Measured by Oxygen-17 Nuclear Magnetic Resonance |
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