Studies on Antibacterial Agents. III

Studies on Antibacterial Agents. III

A series of substituted 4-oxoquinoline-3-carboxylic acids having a methyl group at the 8-position was prepared and tested for their antibacterial activity. 7-(trans-3-Amino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-1, 4-dihydro-6-fluoro-8-methyl-4-oxoquinoline-3-carboxylic acid (21) exhibited highly po...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1990-09, Vol.38 (9), p.2472
Hauptverfasser: MIYAMOTO, Hisashi, UEDA, Hiraki, OTSUKA, Tatsuya, AKI, Sinji, TAMAOKA, Hisashi, TOMINAGA, Michiaki, NAKAGAWA, Kazuyuki
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Sprache:eng
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Zusammenfassung:A series of substituted 4-oxoquinoline-3-carboxylic acids having a methyl group at the 8-position was prepared and tested for their antibacterial activity. 7-(trans-3-Amino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-1, 4-dihydro-6-fluoro-8-methyl-4-oxoquinoline-3-carboxylic acid (21) exhibited highly potent antibacterial activity against both gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa.
ISSN:0009-2363
1347-5223