Synthesis of Diazipine and [3H]Diazipine
Diazipine and [3H]diazipine were synthesized as new 1, 4-dihydropyridine photoaffinity ligands containing a phenyldiazirine group. After simple high performance liquid chromatography separation, both compounds were purified in good overall yields. [3H]Diazipine (21.2Ci/mmol) was synthesized in two s...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1991-07, Vol.39 (7), p.1860 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Diazipine and [3H]diazipine were synthesized as new 1, 4-dihydropyridine photoaffinity ligands containing a phenyldiazirine group. After simple high performance liquid chromatography separation, both compounds were purified in good overall yields. [3H]Diazipine (21.2Ci/mmol) was synthesized in two steps from commercially available [3H]ethanolamine. Diazipine competitively inhibited [3H]PN200-110 binding to the calcium channel of cardiac membranes with high affinity. |
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| ISSN: | 0009-2363 1347-5223 |