Inhibitors of Xanthine Oxidase from Alpinia galanga

Inhibitors of Xanthine Oxidase from Alpinia galanga

Xanthine oxidase (XO) inhibitors were isolated from the rhizomes of Alpinia galanga (Zingiberaceae), and were identified as trans-p-coumaryl diacetate (1), trans-coniferyl diacetate (2), [1'S]-1'-acetoxychavicol acetate (3), [1'S]-1'-acetoxyeugenol acetate (4) and 4-hydroxybenzal...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1988/01/25, Vol.36(1), pp.244-248
Hauptverfasser: NORO, TADATAKA, SEKIYA, TAKESHI, ABE), MASAKO KATOH(nee, ODA, YASUSHI, MIYASE, TOSHIO, KUROYANAGI, MASANORI, UENO, AKIRA, FUKUSHIMA, SEIGO
Format: Artikel
Sprache:eng
Schlagworte:
1'-acetoxychavicol diacetate phenylpropenol
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
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Zusammenfassung:Xanthine oxidase (XO) inhibitors were isolated from the rhizomes of Alpinia galanga (Zingiberaceae), and were identified as trans-p-coumaryl diacetate (1), trans-coniferyl diacetate (2), [1'S]-1'-acetoxychavicol acetate (3), [1'S]-1'-acetoxyeugenol acetate (4) and 4-hydroxybenzaldehyde (5). The type of inhibition by either 1 or 3 with respect to xanthine as a substrate was uncompetitive.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.36.244