Species, Strain, Sex and Weekly Age Differences of Lipid Peroxide Levels in Animals Tissues before and after Adriamycin Administration

We investigated which laboratory animal would be the most suitable for studies on the mechanism of adriamycin (ADR)-induced lipid peroxidation. Lipid peroxide (LPO) levels of the main organs on the 3rd day after ADR administration (when a remarkable increase of LPO level in mouse heart was seen) were determined. Both the normal LPO levels and the increase ratios of LPO levels after ADR administration in all the studied tissues of mice, except for the serum, were higher than those in rats and guinea pigs. Next, strain differences in 9 strains of male mice (DDY, ICR, C3H, BALB/c, C57BL, DBA/2, BDF1, CDF1 and B6C3F1) were examined, and clear strain differences were recognized. Further, sex and weekly age differences of LPO tissue levels in CDF1 strain mice were shown. It was concluded that DBA/2 and CDF1 strains of male mice were the most suitable laboratory animals for studies of the mechanism of the lipid peroxidation induced by ADR.