Uracil Derivatives. III. Syntheses and Growth-inhibitory Activity against L-1210 Cells of 5, 6-Disubstituted Uracils

Uracil Derivatives. III. Syntheses and Growth-inhibitory Activity against L-1210 Cells of 5, 6-Disubstituted Uracils

5-(4-Halophenylthiomethyl)-6-alkoxycarbonyluracils (IIa-i) and 5-(4-halophenylthiomethyl)-6-alkylcarbamoyluracils (IVa-p) were prepared from 5-(4-halophenylthiomethyl)-6-ethoxycarbonyluracils (Ia-c). The compounds thus prepared were examined for growth inhibition of L-1210 cells in vitro.

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1982/01/25, Vol.30(1), pp.91-96
Hauptverfasser: OKADA, JUTARO, NAKANO, KOICHI, MIYAKE, HIROSHI, YASUFUKU, SHOJI
Format: Artikel
Sprache:eng
Schlagworte:
L-1210 cells
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Zusammenfassung:5-(4-Halophenylthiomethyl)-6-alkoxycarbonyluracils (IIa-i) and 5-(4-halophenylthiomethyl)-6-alkylcarbamoyluracils (IVa-p) were prepared from 5-(4-halophenylthiomethyl)-6-ethoxycarbonyluracils (Ia-c). The compounds thus prepared were examined for growth inhibition of L-1210 cells in vitro.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.30.91