Simultaneous Determination of Acid Dissociation Constants and True Partition Coefficients by Analysis of the Apparent Partition Coefficients. II. Dibasic Acid and Diacidic Base

The simultaneous determination of acid dissociation constants (pKa) and true partition coefficients (P) of a dibasic acid and a diacidic base was achieved by analyzing the pH dependence of the apparent partition coefficient (Pa). Equations derived theoretically show a parabolic relation of Pa to (H+)-1 and (H+) for a dibasic acid and a diacidic base, respectively, (H+) being the proton concentration. Theoretical considerations indicate