Studies on Peptides. XCVII. Synthesis of Porcine Glu8-Vasoactive Intestinal Polypeptide (VIP)

The synthesis of Glu8-vasoactive intestinal polypeptide (porcine VIP) is described. A 1 M solution of trifluoromethanesulfonic acid-thioanisole (1 : 1 equiv.) in TFA was found to cleave all the protecting groups employed, Z, Z (OMe), Bzl and Mts, suppressing the acid-catalyzed aminosuccinimide forma...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1980/07/25, Vol.28(7), pp.2265-2269
Hauptverfasser:	TAKEYAMA, MASAHARU, KOYAMA, KANAME, YAJIMA, HARUAKI, MORIGA, MOTOYUKI, AONO, MITSURU, MURAKAMI, MOTONOBU
Format:	Artikel
Sprache:	eng
Schlagworte:	pancreatic secretory activity
Online-Zugang:	Volltext
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Zusammenfassung:	The synthesis of Glu8-vasoactive intestinal polypeptide (porcine VIP) is described. A 1 M solution of trifluoromethanesulfonic acid-thioanisole (1 : 1 equiv.) in TFA was found to cleave all the protecting groups employed, Z, Z (OMe), Bzl and Mts, suppressing the acid-catalyzed aminosuccinimide formation of the Asp residue (position 3) with the free carboxyl group. The activity of Glu8-VIP was 1/7-1/8 of that of synthetic porcine VIP.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.28.2265