Synthesis of 1, 3-Bridged 1, 2, 3, 4, 5, 6-Hexahydro-2, 6-methano-3-benzazocine Derivatives

Synthesis of 1, 3-Bridged 1, 2, 3, 4, 5, 6-Hexahydro-2, 6-methano-3-benzazocine Derivatives

Two 1, 3-bridged 1, 2, 3, 4, 5, 6-hexahydro-2, 6-methano-3-benzazocine derivatives (1 and 2) have been synthesized starting from 3, 6-dimethyl-8-methoxy-1, 2, 3, 4, 5, 6-hexahydro-2, 6-methano-3-benzazocine 3 as shown in Chart 1. Compounds 1 and 2 showed no significant analgesic activity.

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1980/06/25, Vol.28(6), pp.1928-1931
Hauptverfasser: SHIOTANI, SHUNSAKU, KOMETANI, TADASHI
Format: Artikel
Sprache:eng
Schlagworte:
NaBH4
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Zusammenfassung:Two 1, 3-bridged 1, 2, 3, 4, 5, 6-hexahydro-2, 6-methano-3-benzazocine derivatives (1 and 2) have been synthesized starting from 3, 6-dimethyl-8-methoxy-1, 2, 3, 4, 5, 6-hexahydro-2, 6-methano-3-benzazocine 3 as shown in Chart 1. Compounds 1 and 2 showed no significant analgesic activity.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.28.1928