Facile Preparation of 5-(3-Indolylmethylene) hydantoins
A facile preparation of 5-(3-indolylmethylene) hydantoins, which are useful intermediates for syntheses of tryptophan and its derivatives, was achieved by condensation of hydantoin with 3-(aminomethylene)-3H-indoles formed in situ by the reaction of indoles with Vilsmeier-Haack reagent followed by n...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1980/06/25, Vol.28(6), pp.1891-1893 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | A facile preparation of 5-(3-indolylmethylene) hydantoins, which are useful intermediates for syntheses of tryptophan and its derivatives, was achieved by condensation of hydantoin with 3-(aminomethylene)-3H-indoles formed in situ by the reaction of indoles with Vilsmeier-Haack reagent followed by neutralization with anhydrous bases. |
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| ISSN: | 0009-2363 1347-5223 |
| DOI: | 10.1248/cpb.28.1891 |