Studies on Pyrimidine Derivatives. XX. Synthetic Utility of Hydroxymethylpyrimidines and Related Compounds

Studies on Pyrimidine Derivatives. XX. Synthetic Utility of Hydroxymethylpyrimidines and Related Compounds

The conversion of a hydroxymethyl group at the 2- or 4-position of simple pyrimidines to a chloromethyl, cyanomethyl, ethoxycarbonylmethyl, or formyl group is described. Various pyrimidines having an olefinic side chain were also synthesized via the Wittig reagents derived from chloromethylpyrimidin...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1980/11/25, Vol.28(11), pp.3362-3368
Hauptverfasser: SAKAMOTO, TAKAO, TANJI, KENICHI, NIITSUMA, SETSUKO, ONO, TAKAYASU, YAMANAKA, HIROSHI
Format: Artikel
Sprache:eng
Schlagworte:
Wittig reaction
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Zusammenfassung:The conversion of a hydroxymethyl group at the 2- or 4-position of simple pyrimidines to a chloromethyl, cyanomethyl, ethoxycarbonylmethyl, or formyl group is described. Various pyrimidines having an olefinic side chain were also synthesized via the Wittig reagents derived from chloromethylpyrimidines.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.28.3362