Acetic Acid-Catalyzed Diketopiperazine Synthesis

Acetic Acid-Catalyzed Diketopiperazine Synthesis

Optically pure diketopiperazines were obtained in good yields when dipeptide esters were refluxed in 2-butanol containing 0.1 M acetic acid for 3 hours. When prolyl-amino acid ester was used as the starting material, 1 to 2 M acetic acid was the most effective concentration.

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1981/01/25, Vol.29(1), pp.233-237
Hauptverfasser: SUZUKI, KENJI, SASAKI, YUSUKE, ENDO, NOBUYOSHI, MIHARA, YUICHI
Format: Artikel
Sprache:eng
Schlagworte:
racemization test
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Zusammenfassung:Optically pure diketopiperazines were obtained in good yields when dipeptide esters were refluxed in 2-butanol containing 0.1 M acetic acid for 3 hours. When prolyl-amino acid ester was used as the starting material, 1 to 2 M acetic acid was the most effective concentration.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.29.233