Synthesis of the Metabolites of 2-(N-Benzyl-N-methylamino)ethyl Methyl 2, 6-Dimethyl-4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate Hydrochloride (Nicardipine Hydrochloride, YC-93)

Synthesis of the Metabolites of 2-(N-Benzyl-N-methylamino)ethyl Methyl 2, 6-Dimethyl-4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate Hydrochloride (Nicardipine Hydrochloride, YC-93)

Eight metabolites (M-1-M-6, M-8, M-9) of 2-(N-benzyl-N-methylamino)ethyl methyl 2, 6-dimethyl-4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate hydrochloride (YC-93) were synthesized and the structures of the metabolites were established by comparison with the synthetic compounds.

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1980/09/25, Vol.28(9), pp.2609-2613
Hauptverfasser: SHIBANUMA, TADAO, IWANAMI, MASARU, FUJIMOTO, MASAHARU, TAKENAKA, TOICHI, MURAKAMI, MASUO
Format: Artikel
Sprache:eng
Schlagworte:
vasodilator
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Zusammenfassung:Eight metabolites (M-1-M-6, M-8, M-9) of 2-(N-benzyl-N-methylamino)ethyl methyl 2, 6-dimethyl-4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate hydrochloride (YC-93) were synthesized and the structures of the metabolites were established by comparison with the synthetic compounds.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.28.2609