Synthesis of [alpha]-Substituted Alkanoic Acids and Inhibition of Platelet Aggregation

Synthesis of [alpha]-Substituted Alkanoic Acids and Inhibition of Platelet Aggregation

A series of 4-substituted phenyl-(A, B) and 5-substituted 2-thienyl-(C) acetic acid derivatives were synthesized. Inhibitory activity of collagen-induced rabbit platelet aggregation of 29 compounds including A, B, C and the intermediate compounds of them was studied. Compounds (A-18, B-21 and -27) w...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1978-03, Vol.26 (3), p.685
Hauptverfasser: YOSHIMURA, SHOJI, TAKAHASHI, SUSUMU, KAWAMATA, AKIRA, KIKUGAWA, KIYOMI, SUEHIRO, HIDEO, AOKI, AKIJI
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Sprache:eng
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Zusammenfassung:A series of 4-substituted phenyl-(A, B) and 5-substituted 2-thienyl-(C) acetic acid derivatives were synthesized. Inhibitory activity of collagen-induced rabbit platelet aggregation of 29 compounds including A, B, C and the intermediate compounds of them was studied. Compounds (A-18, B-21 and -27) were inhibitory against platelet aggregation and the most potent compound (B-21) was more effective than aspirin.
ISSN:0009-2363
1347-5223