Synthesis of 1, 5-Benzothiazepine Derivatives. III

Synthesis of 1, 5-Benzothiazepine Derivatives. III

Various derivatives of 2-aryl-3-hydroxy-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one (I) were synthesized. Alternative routes to 2-aryl-3-hydroxy-5-alkyl-trans-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one (II-β) and 2-aryl-3-acetoxy-5-dimethylaminoethyl-cis-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1971/03/25, Vol.19(3), pp.595-602
Hauptverfasser: KUGITA, HIROSHI, INOUE, HIROZUMI, IKEZAKI, MUNEYOSHI, KONDA, MIKIHIKO, TAKEO, SATOSHI
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Sprache:eng
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Zusammenfassung:Various derivatives of 2-aryl-3-hydroxy-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one (I) were synthesized. Alternative routes to 2-aryl-3-hydroxy-5-alkyl-trans-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one (II-β) and 2-aryl-3-acetoxy-5-dimethylaminoethyl-cis-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one (VI-α) were also investigated respectively.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.19.595