Studies of Tenuazonic Acid Analogs. I. Synthesis of 5-Substituted 3-(1'-Anilinoethylidene) pyrrolidine-2, 4-dione

Derivatives of tenuazonic acid, 3-acetyl-5-sec-butyltetramic acid, were synthesized. 5-Substituted 3-acetyl tetramic acids were condensed with primary aromatic amines refluxing in alcohol. The structure of the condensation products were determined as 5-substituted 3-(1'-anilinoethylidene) pyrrolidine-2, 4-dione. The stability of the one of the condensation products was investigated, and it was found to be stable in acidic and neutral, but unstable in alkaline medium.