Resonance Transfer of Excitation Energy between Non-steroidal Anti-inflammatory Drugs and Aromatic Amino Acids

The critical distance, R0, which is the rate parameter for the transfer of excitation energy by resonance between aromatic amino acids and 14 kinds of non-steroidal anti-inflammatory drugs or some of other aromatic compounds was calculated. The rank correlation between the R0 values and anti-inflammatory activity were found to be significant, and the activity of various nonsteroidal anti-inflammatory drugs were illustrated uniformly at a molecular level. Finally, a possibility of formation of electronic excited state of aromatic amino acid residues in living cell was discussed.