Potential Anti-cancer Agents. IV. 3-Substituted 6-Chloropyridazine 1-Oxides

Potential Anti-cancer Agents. IV. 3-Substituted 6-Chloropyridazine 1-Oxides

When 3, 6-dichloropyridazine and 3-alkoxy-6-chloropyridazines were oxidized with monoperphthalic acid or hydrogen peroxide-glacial acetic acid, the corresponding Noxides were produced. With the latter reagent, however, 6-substituted-3(2H)-pyridazinones gave rise to byproducts. The N-oxidation of 3-a...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1962/10/25, Vol.10(10), pp.989-992
Hauptverfasser: Itai, Takanobu, Sako, Shigeru
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Sprache:eng
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Antineoplastic Agents
Humans
Oxides
Pyridazines
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Sako, Shigeru
description When 3, 6-dichloropyridazine and 3-alkoxy-6-chloropyridazines were oxidized with monoperphthalic acid or hydrogen peroxide-glacial acetic acid, the corresponding Noxides were produced. With the latter reagent, however, 6-substituted-3(2H)-pyridazinones gave rise to byproducts. The N-oxidation of 3-alkoxy-6-chloropyridazines was shown to take place at the 1-position of the molecules. By catalytic dehalogenation, several 3-alkoxypyridazine 1-oxides were also prepared.
doi_str_mv 10.1248/cpb.10.989
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subjects Antineoplastic Agents
Humans
Oxides
Pyridazines
title Potential Anti-cancer Agents. IV. 3-Substituted 6-Chloropyridazine 1-Oxides
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