Potential Anti-cancer Agents. IV. 3-Substituted 6-Chloropyridazine 1-Oxides

When 3, 6-dichloropyridazine and 3-alkoxy-6-chloropyridazines were oxidized with monoperphthalic acid or hydrogen peroxide-glacial acetic acid, the corresponding Noxides were produced. With the latter reagent, however, 6-substituted-3(2H)-pyridazinones gave rise to byproducts. The N-oxidation of 3-alkoxy-6-chloropyridazines was shown to take place at the 1-position of the molecules. By catalytic dehalogenation, several 3-alkoxypyridazine 1-oxides were also prepared.