Synthesis of Non-Steroidal Estrogen Receptor Antagonists R1128 A, B, C, and D via an Oxazoline-Promoted Iterative ortho-Lithiation Strategy

Synthesis of Non-Steroidal Estrogen Receptor Antagonists R1128 A, B, C, and D via an Oxazoline-Promoted Iterative ortho-Lithiation Strategy

A concise total synthesis of non-steroidal estrogen receptor antagonists R1128 A–D (1a–1d) has been achieved using iterative ortho-lithiation of 2-(4-methoxyphenyl)-4,4-dimethyloxazoline (3) as the key reaction.

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Veröffentlicht in:Bulletin of the Chemical Society of Japan 2012, Vol.85 (1), p.133-135
Hauptverfasser: Fukuda, Tsutomu, Fukushima, Koichiro, Sanai, Susumu, Iwao, Masatomo
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container_title Bulletin of the Chemical Society of Japan
container_volume 85
creator Fukuda, Tsutomu
Fukushima, Koichiro
Sanai, Susumu
Iwao, Masatomo
description A concise total synthesis of non-steroidal estrogen receptor antagonists R1128 A–D (1a–1d) has been achieved using iterative ortho-lithiation of 2-(4-methoxyphenyl)-4,4-dimethyloxazoline (3) as the key reaction.
doi_str_mv 10.1246/bcsj.20110243
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title Synthesis of Non-Steroidal Estrogen Receptor Antagonists R1128 A, B, C, and D via an Oxazoline-Promoted Iterative ortho-Lithiation Strategy
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