Synthesis of Non-Steroidal Estrogen Receptor Antagonists R1128 A, B, C, and D via an Oxazoline-Promoted Iterative ortho-Lithiation Strategy

Synthesis of Non-Steroidal Estrogen Receptor Antagonists R1128 A, B, C, and D via an Oxazoline-Promoted Iterative ortho-Lithiation Strategy

A concise total synthesis of non-steroidal estrogen receptor antagonists R1128 A–D (1a–1d) has been achieved using iterative ortho-lithiation of 2-(4-methoxyphenyl)-4,4-dimethyloxazoline (3) as the key reaction.

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Veröffentlicht in:Bulletin of the Chemical Society of Japan 2012, Vol.85 (1), p.133-135
Hauptverfasser: Fukuda, Tsutomu, Fukushima, Koichiro, Sanai, Susumu, Iwao, Masatomo
Format: Artikel
Sprache:eng
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Zusammenfassung:A concise total synthesis of non-steroidal estrogen receptor antagonists R1128 A–D (1a–1d) has been achieved using iterative ortho-lithiation of 2-(4-methoxyphenyl)-4,4-dimethyloxazoline (3) as the key reaction.
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.20110243