The Influence of Protecting Groups on the [beta]-Sheet-Structure Stability of Protected Peptides

The influence of protecting groups on the β-sheet-structure stability of protected peptides was studied in organic solvents. α-Amino groups, carboxyl groups, and side-chain functional groups of model peptides were protected by availably used protecting groups. The difference between the solubilities of model peptides was investigated by the solvent-titration method using infrared (IR) absorption spectra. The β-sheet-structure-stabilizing potentials (SPβ) of each protecting group showed similar behaviors, except for Npys, Mts, and Z2. The result exhibits that the values of the protected peptide are almost independent of the kinds of their protecting group.