Visualization of 3D retinal microcapillary network using OCT

Purpose To present a novel method for noninvasive visualization of 3D retinal microcapillary network (RMN) using optical coherence tomography (OCT) reflectivity maps and to validate its clinical usefulness in vascular retinal diseases. Methods OCT imaging was applied to 43 patients with diabetic retinopathy, CRVO, BRVO and in 13 healthy subjects. OCT maps of RMN from different retinal layers were reconstructed and compared with fluorescein angiography. Results OCT showed the RMN of 20 microns in diameter, revealed vascular nonperfusion and identified microexudates that were not visible on clinical examination and fundus photography. Conclusion OCT is capable to precisely detect the RMN and can be used for noninvasive diagnosis and monitoring of early stages of retinal vascular diseases.