Cytotoxic Steroids from the Trunk of Berberis koreana
A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity agains...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2012, Vol.76 (4), p.825-827 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | KIM, Ki Hyun CHOI, Sang Un KIM, Chung Sub LEE, Kang Ro |
| description | A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (respective IC
50
values of 7.41, 9.20, 4.53, and 12.91 μM). |
| doi_str_mv | 10.1271/bbb.110751 |
| format | Article |
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50
values of 7.41, 9.20, 4.53, and 12.91 μM).</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.110751</identifier><identifier>PMID: 22484929</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject><![CDATA[Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Berberidaceae ; Berberis ; Berberis - chemistry ; Berberis koreana ; Biological and medical sciences ; Cell Line, Tumor ; cytotoxicity ; Drug Screening Assays, Antitumor ; Fundamental and applied biological sciences. Psychology ; Humans ; Inhibitory Concentration 50 ; itesmol 3-O-palmitate ; Magnetic Resonance Spectroscopy ; Palmitates - chemistry ; Palmitates - isolation & purification ; Palmitates - pharmacology ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; steroid ; Steroids - chemistry ; Steroids - isolation & purification ; Steroids - pharmacology ; Stigmasterol - analogs & derivatives ; Stigmasterol - chemistry ; Stigmasterol - isolation & purification ; Stigmasterol - pharmacology ; Wood - chemistry]]></subject><ispartof>Bioscience, biotechnology, and biochemistry, 2012, Vol.76 (4), p.825-827</ispartof><rights>2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c642t-2e18e749e275e52ed501a7f74724298db97e21f7b710083e60cad414e4e569b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26176422$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22484929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIM, Ki Hyun</creatorcontrib><creatorcontrib>CHOI, Sang Un</creatorcontrib><creatorcontrib>KIM, Chung Sub</creatorcontrib><creatorcontrib>LEE, Kang Ro</creatorcontrib><title>Cytotoxic Steroids from the Trunk of Berberis koreana</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (respective IC
50
values of 7.41, 9.20, 4.53, and 12.91 μM).</description><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Berberidaceae</subject><subject>Berberis</subject><subject>Berberis - chemistry</subject><subject>Berberis koreana</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>cytotoxicity</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>itesmol 3-O-palmitate</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Palmitates - chemistry</subject><subject>Palmitates - isolation & purification</subject><subject>Palmitates - pharmacology</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>steroid</subject><subject>Steroids - chemistry</subject><subject>Steroids - isolation & purification</subject><subject>Steroids - pharmacology</subject><subject>Stigmasterol - analogs & derivatives</subject><subject>Stigmasterol - chemistry</subject><subject>Stigmasterol - isolation & purification</subject><subject>Stigmasterol - pharmacology</subject><subject>Wood - chemistry</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0F1LwzAUBuAgipvTG3-AFEQQoTMnTZrmUodfMPDC3Ze0PcVubaNJi-7fm9FNQbzwKhCe83LOS8gp0CkwCddZlk0BqBSwR8YQcRnGist9MqYK4jDhAkbkyLklpf5DwCEZMcYTrpgaEzFbd6Yzn1UevHRoTVW4oLSmCbpXDBa2b1eBKYNbtBnaygUrY1G3-pgclLp2eLJ9J2Rxf7eYPYbz54en2c08zGPOupAhJCi5QiYFCoaFoKBlKblknKmkyJREBqXMJFCaRBjTXBccOHIUscqiCbkcYt-see_RdWlTuRzrWrdoepcCjXjC_LHsH9Tfzrzc0PNfdGl62_o7UuBcJcInJl5dDSq3xjmLZfpmq0bbtY9KN7WnvvZ0qN3js21knzVYfNNdzx5cbIF2ua5Lq9u8cj8uBhkPu4nBVW1pbKM_jK2LtNPr2tjdUPTHAl-eH5jn</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>KIM, Ki Hyun</creator><creator>CHOI, Sang Un</creator><creator>KIM, Chung Sub</creator><creator>LEE, Kang Ro</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>2012</creationdate><title>Cytotoxic Steroids from the Trunk of Berberis koreana</title><author>KIM, Ki Hyun ; CHOI, Sang Un ; KIM, Chung Sub ; LEE, Kang Ro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c642t-2e18e749e275e52ed501a7f74724298db97e21f7b710083e60cad414e4e569b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Berberidaceae</topic><topic>Berberis</topic><topic>Berberis - chemistry</topic><topic>Berberis koreana</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>cytotoxicity</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>itesmol 3-O-palmitate</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Palmitates - chemistry</topic><topic>Palmitates - isolation & purification</topic><topic>Palmitates - pharmacology</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>steroid</topic><topic>Steroids - chemistry</topic><topic>Steroids - isolation & purification</topic><topic>Steroids - pharmacology</topic><topic>Stigmasterol - analogs & derivatives</topic><topic>Stigmasterol - chemistry</topic><topic>Stigmasterol - isolation & purification</topic><topic>Stigmasterol - pharmacology</topic><topic>Wood - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIM, Ki Hyun</creatorcontrib><creatorcontrib>CHOI, Sang Un</creatorcontrib><creatorcontrib>KIM, Chung Sub</creatorcontrib><creatorcontrib>LEE, Kang Ro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIM, Ki Hyun</au><au>CHOI, Sang Un</au><au>KIM, Chung Sub</au><au>LEE, Kang Ro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic Steroids from the Trunk of Berberis koreana</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2012</date><risdate>2012</risdate><volume>76</volume><issue>4</issue><spage>825</spage><epage>827</epage><pages>825-827</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (respective IC
50
values of 7.41, 9.20, 4.53, and 12.91 μM).</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>22484929</pmid><doi>10.1271/bbb.110751</doi><tpages>3</tpages></addata></record> |
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| ispartof | Bioscience, biotechnology, and biochemistry, 2012, Vol.76 (4), p.825-827 |
| issn | 0916-8451 1347-6947 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Free Full-Text Journals in Chemistry |
| subjects | Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Berberidaceae Berberis Berberis - chemistry Berberis koreana Biological and medical sciences Cell Line, Tumor cytotoxicity Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology Humans Inhibitory Concentration 50 itesmol 3-O-palmitate Magnetic Resonance Spectroscopy Palmitates - chemistry Palmitates - isolation & purification Palmitates - pharmacology Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology steroid Steroids - chemistry Steroids - isolation & purification Steroids - pharmacology Stigmasterol - analogs & derivatives Stigmasterol - chemistry Stigmasterol - isolation & purification Stigmasterol - pharmacology Wood - chemistry |
| title | Cytotoxic Steroids from the Trunk of Berberis koreana |
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