Cytotoxic Steroids from the Trunk of Berberis koreana

A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity agains...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2012, Vol.76 (4), p.825-827
Hauptverfasser:	KIM, Ki Hyun, CHOI, Sang Un, KIM, Chung Sub, LEE, Kang Ro
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Berberidaceae Berberis Berberis - chemistry Berberis koreana Biological and medical sciences Cell Line, Tumor cytotoxicity Drug Screening Assays, Antitumor Fundamental and applied biological sciences. Psychology Humans Inhibitory Concentration 50 itesmol 3-O-palmitate Magnetic Resonance Spectroscopy Palmitates - chemistry Palmitates - isolation & purification Palmitates - pharmacology Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology steroid Steroids - chemistry Steroids - isolation & purification Steroids - pharmacology Stigmasterol - analogs & derivatives Stigmasterol - chemistry Stigmasterol - isolation & purification Stigmasterol - pharmacology Wood - chemistry
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Beschreibung
Zusammenfassung:	A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (respective IC 50 values of 7.41, 9.20, 4.53, and 12.91 μM).
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.110751