Synthetic Studies on Kohamaic Acids

Synthetic Studies on Kohamaic Acids

Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships.

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2008-11, Vol.72 (11), p.3071
Hauptverfasser: TAKIKAWA, Hirosato, KAMATANI, Naoki, NAKANISHI, Kohei, TASHIRO, Takuya, SASAKI, Mitsuru, YOSHIDA, Hiromi, MIZUSHINA, Yoshiyuki
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Sprache:eng
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Zusammenfassung:Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships.
ISSN:0916-8451
1347-6947