Effect of synthetic hydroxy isothiocyanates on a bacterial virus and DNA

The Effect of hydroxy isothiocyanates on a bacterial virus and M13 DNA was examined. Hydroxy-substituted phenyl and phenyl alkyl isothiocyanates, especially 2-(3,4-dihydroxyphenyl)ethyl isothiocyanate(IT-Dop) synthesized from dopamine, showed antiviral activity on phiK. In transfection experiments w...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-04, Vol.71 (4), p.1094-1097
Hauptverfasser:	Tajima, H.(Kanazawa Univ. (Japan)), Nakamoto, Y, Taketo, A
Format:	Artikel
Sprache:	eng
Schlagworte:	2-(3,4-dihydroxyphenyl)ethyl isothiocyanate ADN ANTIVIRAL ANTIVIRAL AGENTS Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Bacteria Bacteriophage M13 - drug effects Bacteriophage M13 - radiation effects Biological and medical sciences CHEMICAL SYNTHESIS DNA DNA Replication - drug effects DNA, Bacterial - chemistry DNA, Viral - drug effects DNA, Viral - radiation effects DOPAMINA DOPAMINE Escherichia coli - chemistry Fundamental and applied biological sciences. Psychology hydroxy isothiocyanate Hydroxylation Isothiocyanates - chemical synthesis Isothiocyanates - pharmacology Kinetics Nucleic Acid Denaturation SINTESIS QUIMICA Structure-Activity Relationship SYNTHESE CHIMIQUE THIOCYANATE THIOCYANATES TIOCIANATOS TRANSFECCION TRANSFECTION Ultraviolet Rays VIRICIDAS VIRUS VIRUSES
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Zusammenfassung:	The Effect of hydroxy isothiocyanates on a bacterial virus and M13 DNA was examined. Hydroxy-substituted phenyl and phenyl alkyl isothiocyanates, especially 2-(3,4-dihydroxyphenyl)ethyl isothiocyanate(IT-Dop) synthesized from dopamine, showed antiviral activity on phiK. In transfection experiments with M13 mp DNA species, IT-Dop inhibited the single-stranded (SS) molecule more effectively than the double stranded replicative form (RF) DNA. These effects were dependent on reaction time, and on IT-Dop concentration. An additional experiment indicated that treatment with IT-Dop suppressed annealing (reassociation) of denatured DNA. These results indicate that IT-Dop reacts mildly with virus and SS DNA.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.70001