Prevention by polyhydroxysteroids and saponins of Asterina pectinifera of the desquamation of stratum corneum cells

Two polyhydroxysteroids and three steroidal saponins (pectiniosides A, B and C) were isolated as bioactive substances from Asterina pectinifera. These compounds inhibited the release of guinea-pig skin stratum corneum cells by 48-67% (control, 0%) at 2 mg/ml. It is suggested that the bioactivity of...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2002-04, Vol.66 (4), p.913-915
Hauptverfasser:	Ukai, K. (Tokyo Univ. of Fisheries (Japan)), Iwanaga, A, Nagai, H, Namikoshi, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asterina pectinifera ASTEROIDEA Biological and medical sciences Carbohydrate Sequence CELLS desquamation Echinodermata General pharmacology GUINEA PIGS Humans Hydroxysteroids - therapeutic use KERATIN Medical sciences Molecular Sequence Data Oligosaccharides - chemistry Oligosaccharides - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments polyhydroxysteroid RESECTION SAPONINS Saponins - therapeutic use SKIN Skin - drug effects Skin - pathology Skin Aging - drug effects Skin Diseases - prevention & control steroidal saponin STEROIDS stratum corneum
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Zusammenfassung:	Two polyhydroxysteroids and three steroidal saponins (pectiniosides A, B and C) were isolated as bioactive substances from Asterina pectinifera. These compounds inhibited the release of guinea-pig skin stratum corneum cells by 48-67% (control, 0%) at 2 mg/ml. It is suggested that the bioactivity of these compounds is connected with the remedial and preventive effects of an aqueous extract of A. pectinifera on rough human skin.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.66.913