Synthesis of Macrotetrolide [alpha], a Designed Polynactin Analog Composed of (+)- and (-)-Bishomononactic Acids

Synthesis of Macrotetrolide [alpha], a Designed Polynactin Analog Composed of (+)- and (-)-Bishomononactic Acids

Macrotetrolide α, a designed analog of polynactin composed of (+)- and (-)-bishomononactic acids, was synthesized. These monomers were prepared via optical resoiution of the corresponding (S)-O-acetylmandelates. Assembly of the monomers to macrotetrolide α took seven steps without any loss of the in...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2001-09, Vol.65 (9), p.2118
Hauptverfasser: HANADATE, Tadaatsu, KIYOTA, Hiromasa, ORITANI, Takayuki
Format: Artikel
Sprache:eng
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Zusammenfassung:Macrotetrolide α, a designed analog of polynactin composed of (+)- and (-)-bishomononactic acids, was synthesized. These monomers were prepared via optical resoiution of the corresponding (S)-O-acetylmandelates. Assembly of the monomers to macrotetrolide α took seven steps without any loss of the intermediates.
ISSN:0916-8451
1347-6947