Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B

We performed a screening program to identify telomerase inhibitors from our drug source obtained from fungus fermentations, and found that two compounds, CRM646-A and thielavin B, inhibited telomerase activity at doses of 3.2 and 32 μM, respectively. These compounds also inhibited the activity of vi...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2001-03, Vol.65 (3), p.651-653
Hauptverfasser:	Togashi, K. (Institute of Physical and Chemical Research, Wako, Saitama (Japan)), Ko, H.R, Ahn, J.S, Osada, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CRM646-A Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology ENZYMES Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology FUNGI Humans Hydroxybenzoates - chemistry Hydroxybenzoates - pharmacology MANKIND Medical sciences METABOLITES METHODS Molecular Structure NEOPLASMS Pharmacology. Drug treatments reverse transcriptase screening telomerase Telomerase - antagonists & inhibitors Telomerase - metabolism TESTING thielavin B Transferases U937 Cells
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Zusammenfassung:	We performed a screening program to identify telomerase inhibitors from our drug source obtained from fungus fermentations, and found that two compounds, CRM646-A and thielavin B, inhibited telomerase activity at doses of 3.2 and 32 μM, respectively. These compounds also inhibited the activity of viral reverse transcriptase at almost the same dose levels which inhibited telomerase activity.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.65.651