Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1
It was found that a lactase preparation from Penicillium sp. nearly quantitatively hydrolyzed ginsenosides Re and Rg 1 , which are major saponins in roots of Panax ginseng, to a minor saponin, 20(S)-ginsenoside Rh 1 [6-O-β-D-glucopyranosyl-20(S)-protopanaxatriol]. This is the first report on the enz...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2000-12, Vol.64 (12), p.2739-2743 |
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| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 64 |
| creator | Ko, S.R. (Korea Ginseng and Tobacco Research Inst., Taejon (Korea R.)) Suzuki, Y Choi, K.J Kim, Y.H |
| description | It was found that a lactase preparation from Penicillium sp. nearly quantitatively hydrolyzed ginsenosides Re and Rg
1
, which are major saponins in roots of Panax ginseng, to a minor saponin, 20(S)-ginsenoside Rh
1
[6-O-β-D-glucopyranosyl-20(S)-protopanaxatriol]. This is the first report on the enzymatic preparation of ginsenoside Rh
1
with a high efficiency. This enzyme also readily hydrolyzed ginsenoside Rg
2
to ginsenoside Rh
1
. |
| doi_str_mv | 10.1271/bbb.64.2739 |
| format | Article |
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1
, which are major saponins in roots of Panax ginseng, to a minor saponin, 20(S)-ginsenoside Rh
1
[6-O-β-D-glucopyranosyl-20(S)-protopanaxatriol]. This is the first report on the enzymatic preparation of ginsenoside Rh
1
with a high efficiency. This enzyme also readily hydrolyzed ginsenoside Rg
2
to ginsenoside Rh
1
.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.64.2739</identifier><identifier>PMID: 11210151</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>beta-Galactosidase - chemistry ; beta-Galactosidase - metabolism ; Biochemistry - methods ; Biological and medical sciences ; Biotechnology ; ENZYMATIC HYDROLYSIS ; Fundamental and applied biological sciences. Psychology ; ginsenoside Re ; ginsenoside Rg ; ginsenoside Rh ; GINSENOSIDES ; Health. Pharmaceutical industry ; Hydrolysis ; Industrial applications and implications. Economical aspects ; LACTASE ; Other active biomolecules ; PANAX PSEUDOGINSENG ; PENICILLIUM ; Penicillium sp. lactase ; Production of active biomolecules ; Saponins - chemical synthesis ; Saponins - chemistry ; Saponins - metabolism</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2000-12, Vol.64 (12), p.2739-2743</ispartof><rights>2000 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2000</rights><rights>2001 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=922461$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11210151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ko, S.R. (Korea Ginseng and Tobacco Research Inst., Taejon (Korea R.))</creatorcontrib><creatorcontrib>Suzuki, Y</creatorcontrib><creatorcontrib>Choi, K.J</creatorcontrib><creatorcontrib>Kim, Y.H</creatorcontrib><title>Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>It was found that a lactase preparation from Penicillium sp. nearly quantitatively hydrolyzed ginsenosides Re and Rg
1
, which are major saponins in roots of Panax ginseng, to a minor saponin, 20(S)-ginsenoside Rh
1
[6-O-β-D-glucopyranosyl-20(S)-protopanaxatriol]. This is the first report on the enzymatic preparation of ginsenoside Rh
1
with a high efficiency. This enzyme also readily hydrolyzed ginsenoside Rg
2
to ginsenoside Rh
1
.</description><subject>beta-Galactosidase - chemistry</subject><subject>beta-Galactosidase - metabolism</subject><subject>Biochemistry - methods</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>ENZYMATIC HYDROLYSIS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>ginsenoside Re</subject><subject>ginsenoside Rg</subject><subject>ginsenoside Rh</subject><subject>GINSENOSIDES</subject><subject>Health. Pharmaceutical industry</subject><subject>Hydrolysis</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>LACTASE</subject><subject>Other active biomolecules</subject><subject>PANAX PSEUDOGINSENG</subject><subject>PENICILLIUM</subject><subject>Penicillium sp. lactase</subject><subject>Production of active biomolecules</subject><subject>Saponins - chemical synthesis</subject><subject>Saponins - chemistry</subject><subject>Saponins - metabolism</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1rFEEQxRsxmE305FlpEEQhs_bX9EwfJcSoBJRVz0311zphpnvTvYNs_vr0skkInqrq8XtFUQ-h15QsKevoJ2PMUool67h6hhaUi66RSnTP0YIoKptetPQYnZRyTUgVWvoCHVPKKKntApmLeLubYDtYvMl-A7m2KeIU8NrHeYi-yqnAJtVxiGeYkQ-_PjbrIRYfUxmcx6u_9AyHnCb8RC145TFEh1dr-hIdBRiLf3VfT9GfLxe_z782Vz8uv51_vmqC6KRqeBcscMeJ4yyAbZkTrgfmWg_cEk6M47YPIfQEmPGdaWsxzLoA4GSnFD9F7w9768U3sy9bPQ3F-nGE6NNcdMfaVrQ9r-C7_8DrNOdYb9NUCCW4pIpU6u09NZvJO73JwwR5px9-92QNFAtjyBDtUB45xZiQe0oeqCGGlCf4l_Lo9BZ2Y8oPFk6J3kepa5RaCr2PshrfHIwBkoZ1rtz3n4wQSghvGeV3mXqXhQ</recordid><startdate>200012</startdate><enddate>200012</enddate><creator>Ko, S.R. (Korea Ginseng and Tobacco Research Inst., Taejon (Korea R.))</creator><creator>Suzuki, Y</creator><creator>Choi, K.J</creator><creator>Kim, Y.H</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200012</creationdate><title>Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1</title><author>Ko, S.R. (Korea Ginseng and Tobacco Research Inst., Taejon (Korea R.)) ; Suzuki, Y ; Choi, K.J ; Kim, Y.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f4769-37fca3d30d32fac52d4d8a2d5ea3c030bd3c8fff80a2be7b5a2bb2cdfaad67993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>beta-Galactosidase - chemistry</topic><topic>beta-Galactosidase - metabolism</topic><topic>Biochemistry - methods</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>ENZYMATIC HYDROLYSIS</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>ginsenoside Re</topic><topic>ginsenoside Rg</topic><topic>ginsenoside Rh</topic><topic>GINSENOSIDES</topic><topic>Health. Pharmaceutical industry</topic><topic>Hydrolysis</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>LACTASE</topic><topic>Other active biomolecules</topic><topic>PANAX PSEUDOGINSENG</topic><topic>PENICILLIUM</topic><topic>Penicillium sp. lactase</topic><topic>Production of active biomolecules</topic><topic>Saponins - chemical synthesis</topic><topic>Saponins - chemistry</topic><topic>Saponins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ko, S.R. (Korea Ginseng and Tobacco Research Inst., Taejon (Korea R.))</creatorcontrib><creatorcontrib>Suzuki, Y</creatorcontrib><creatorcontrib>Choi, K.J</creatorcontrib><creatorcontrib>Kim, Y.H</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ko, S.R. (Korea Ginseng and Tobacco Research Inst., Taejon (Korea R.))</au><au>Suzuki, Y</au><au>Choi, K.J</au><au>Kim, Y.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2000-12</date><risdate>2000</risdate><volume>64</volume><issue>12</issue><spage>2739</spage><epage>2743</epage><pages>2739-2743</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>It was found that a lactase preparation from Penicillium sp. nearly quantitatively hydrolyzed ginsenosides Re and Rg
1
, which are major saponins in roots of Panax ginseng, to a minor saponin, 20(S)-ginsenoside Rh
1
[6-O-β-D-glucopyranosyl-20(S)-protopanaxatriol]. This is the first report on the enzymatic preparation of ginsenoside Rh
1
with a high efficiency. This enzyme also readily hydrolyzed ginsenoside Rg
2
to ginsenoside Rh
1
.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>11210151</pmid><doi>10.1271/bbb.64.2739</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2000-12, Vol.64 (12), p.2739-2743 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_proquest_journals_1449436190 |
| source | J-STAGE Free; MEDLINE; Oxford University Press Journals All Titles (1996-Current); Open Access Titles of Japan; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | beta-Galactosidase - chemistry beta-Galactosidase - metabolism Biochemistry - methods Biological and medical sciences Biotechnology ENZYMATIC HYDROLYSIS Fundamental and applied biological sciences. Psychology ginsenoside Re ginsenoside Rg ginsenoside Rh GINSENOSIDES Health. Pharmaceutical industry Hydrolysis Industrial applications and implications. Economical aspects LACTASE Other active biomolecules PANAX PSEUDOGINSENG PENICILLIUM Penicillium sp. lactase Production of active biomolecules Saponins - chemical synthesis Saponins - chemistry Saponins - metabolism |
| title | Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1 |
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