Protection by Trehalose of DNA from Radiation Damage
The most serious damage to cells exposed to radiation is attributed mostly to effects on the structure of cellular DNA. We found that trehalose protects DNA from irradiation. In the presence of 10 mm trehalose, DNA can be protected from about 4 times higher doses of β- and γ-ray irradiation. The pro...
Gespeichert in:
| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1997-01, Vol.61 (1), p.160-161 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 161 |
|---|---|
| container_issue | 1 |
| container_start_page | 160 |
| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 61 |
| creator | Yoshinaga, Koichi Yoshioka, Hiroe Kurosaki, Hiromu Hirasawa, Miyuki Uritani, Masahiro Hasegawa, Kunihiko |
| description | The most serious damage to cells exposed to radiation is attributed mostly to effects on the structure of cellular DNA. We found that trehalose protects DNA from irradiation. In the presence of 10 mm trehalose, DNA can be protected from about 4 times higher doses of β- and γ-ray irradiation. The protective effect increases with the amount of the sugar. Other disaccharides, sucrose, and maltose had similar effects. |
| doi_str_mv | 10.1271/bbb.61.160 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_proquest_journals_1449426372</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16248187</sourcerecordid><originalsourceid>FETCH-LOGICAL-c619t-2a55a36353b6cafe08ab9f977299971fb547fa27c5e4da60e07a313c4825ac5a3</originalsourceid><addsrcrecordid>eNptkM1LHEEQxZsQMavxkntgIOJBmE1Xf04fReMHiAmynpua3u5kZGbadM8S9r-31914EE8FVb_3XvEI-QJ0DkzD97Zt5wrmoOgHMgMudK2M0B_JjBpQdSMkfCIHOT9SWhYS9sm-oayhQsyI-JXi5N3UxbFq19Ui-T_Yx-yrGKqLu7MqpDhU97js8AW5wAF_-89kL2Cf_dFuHpKHyx-L8-v69ufVzfnZbe0UmKlmKCVyxSVvlcPgaYOtCUZrZozREFopdECmnfRiiYp6qpEDd6JhEl2RHpKTre9Tin9XPk926LLzfY-jj6tsQTHRQKML-O0N-BhXaSy_WRDCCKa4ZoU63VIuxZyTD_YpdQOmtQVqN0XaUqRVUHxpgb_uLFft4Jev6K65cj_e3TE77EPC0XX5FWMKKG82mXKLdWOIacB_MfVLO-G6j-m_hr8T_wz42Ioz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449426372</pqid></control><display><type>article</type><title>Protection by Trehalose of DNA from Radiation Damage</title><source>J-STAGE Free</source><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Freely Accessible Japanese Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Yoshinaga, Koichi ; Yoshioka, Hiroe ; Kurosaki, Hiromu ; Hirasawa, Miyuki ; Uritani, Masahiro ; Hasegawa, Kunihiko</creator><creatorcontrib>Yoshinaga, Koichi ; Yoshioka, Hiroe ; Kurosaki, Hiromu ; Hirasawa, Miyuki ; Uritani, Masahiro ; Hasegawa, Kunihiko</creatorcontrib><description>The most serious damage to cells exposed to radiation is attributed mostly to effects on the structure of cellular DNA. We found that trehalose protects DNA from irradiation. In the presence of 10 mm trehalose, DNA can be protected from about 4 times higher doses of β- and γ-ray irradiation. The protective effect increases with the amount of the sugar. Other disaccharides, sucrose, and maltose had similar effects.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.61.160</identifier><identifier>PMID: 9028044</identifier><language>eng</language><publisher>Tokyo: Taylor & Francis</publisher><subject>Beta Particles ; Biological and medical sciences ; Biological effects of radiation ; DNA break ; DNA Damage - drug effects ; DNA Damage - radiation effects ; DNA, Circular - chemistry ; DNA, Circular - drug effects ; DNA, Circular - radiation effects ; DNA, Single-Stranded - chemistry ; DNA, Single-Stranded - drug effects ; DNA, Single-Stranded - radiation effects ; Dose-Response Relationship, Radiation ; Electrophoresis, Agar Gel ; Fundamental and applied biological sciences. Psychology ; Gamma Rays ; irradiation ; Maltose - pharmacology ; Radiation Protection - methods ; Radiation-Protective Agents - pharmacology ; radical scavenger ; Radioprotection ; Sensitivity and Specificity ; Sucrose - pharmacology ; Tissues, organs and organisms biophysics ; trehalose ; Trehalose - pharmacology ; tritium</subject><ispartof>Bioscience, biotechnology, and biochemistry, 1997-01, Vol.61 (1), p.160-161</ispartof><rights>Copyright 1997 Taylor and Francis Group LLC 1997</rights><rights>1997 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c619t-2a55a36353b6cafe08ab9f977299971fb547fa27c5e4da60e07a313c4825ac5a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2610382$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9028044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshinaga, Koichi</creatorcontrib><creatorcontrib>Yoshioka, Hiroe</creatorcontrib><creatorcontrib>Kurosaki, Hiromu</creatorcontrib><creatorcontrib>Hirasawa, Miyuki</creatorcontrib><creatorcontrib>Uritani, Masahiro</creatorcontrib><creatorcontrib>Hasegawa, Kunihiko</creatorcontrib><title>Protection by Trehalose of DNA from Radiation Damage</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The most serious damage to cells exposed to radiation is attributed mostly to effects on the structure of cellular DNA. We found that trehalose protects DNA from irradiation. In the presence of 10 mm trehalose, DNA can be protected from about 4 times higher doses of β- and γ-ray irradiation. The protective effect increases with the amount of the sugar. Other disaccharides, sucrose, and maltose had similar effects.</description><subject>Beta Particles</subject><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>DNA break</subject><subject>DNA Damage - drug effects</subject><subject>DNA Damage - radiation effects</subject><subject>DNA, Circular - chemistry</subject><subject>DNA, Circular - drug effects</subject><subject>DNA, Circular - radiation effects</subject><subject>DNA, Single-Stranded - chemistry</subject><subject>DNA, Single-Stranded - drug effects</subject><subject>DNA, Single-Stranded - radiation effects</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Electrophoresis, Agar Gel</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gamma Rays</subject><subject>irradiation</subject><subject>Maltose - pharmacology</subject><subject>Radiation Protection - methods</subject><subject>Radiation-Protective Agents - pharmacology</subject><subject>radical scavenger</subject><subject>Radioprotection</subject><subject>Sensitivity and Specificity</subject><subject>Sucrose - pharmacology</subject><subject>Tissues, organs and organisms biophysics</subject><subject>trehalose</subject><subject>Trehalose - pharmacology</subject><subject>tritium</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1LHEEQxZsQMavxkntgIOJBmE1Xf04fReMHiAmynpua3u5kZGbadM8S9r-31914EE8FVb_3XvEI-QJ0DkzD97Zt5wrmoOgHMgMudK2M0B_JjBpQdSMkfCIHOT9SWhYS9sm-oayhQsyI-JXi5N3UxbFq19Ui-T_Yx-yrGKqLu7MqpDhU97js8AW5wAF_-89kL2Cf_dFuHpKHyx-L8-v69ufVzfnZbe0UmKlmKCVyxSVvlcPgaYOtCUZrZozREFopdECmnfRiiYp6qpEDd6JhEl2RHpKTre9Tin9XPk926LLzfY-jj6tsQTHRQKML-O0N-BhXaSy_WRDCCKa4ZoU63VIuxZyTD_YpdQOmtQVqN0XaUqRVUHxpgb_uLFft4Jev6K65cj_e3TE77EPC0XX5FWMKKG82mXKLdWOIacB_MfVLO-G6j-m_hr8T_wz42Ioz</recordid><startdate>19970101</startdate><enddate>19970101</enddate><creator>Yoshinaga, Koichi</creator><creator>Yoshioka, Hiroe</creator><creator>Kurosaki, Hiromu</creator><creator>Hirasawa, Miyuki</creator><creator>Uritani, Masahiro</creator><creator>Hasegawa, Kunihiko</creator><general>Taylor & Francis</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope></search><sort><creationdate>19970101</creationdate><title>Protection by Trehalose of DNA from Radiation Damage</title><author>Yoshinaga, Koichi ; Yoshioka, Hiroe ; Kurosaki, Hiromu ; Hirasawa, Miyuki ; Uritani, Masahiro ; Hasegawa, Kunihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c619t-2a55a36353b6cafe08ab9f977299971fb547fa27c5e4da60e07a313c4825ac5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Beta Particles</topic><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>DNA break</topic><topic>DNA Damage - drug effects</topic><topic>DNA Damage - radiation effects</topic><topic>DNA, Circular - chemistry</topic><topic>DNA, Circular - drug effects</topic><topic>DNA, Circular - radiation effects</topic><topic>DNA, Single-Stranded - chemistry</topic><topic>DNA, Single-Stranded - drug effects</topic><topic>DNA, Single-Stranded - radiation effects</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Electrophoresis, Agar Gel</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gamma Rays</topic><topic>irradiation</topic><topic>Maltose - pharmacology</topic><topic>Radiation Protection - methods</topic><topic>Radiation-Protective Agents - pharmacology</topic><topic>radical scavenger</topic><topic>Radioprotection</topic><topic>Sensitivity and Specificity</topic><topic>Sucrose - pharmacology</topic><topic>Tissues, organs and organisms biophysics</topic><topic>trehalose</topic><topic>Trehalose - pharmacology</topic><topic>tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshinaga, Koichi</creatorcontrib><creatorcontrib>Yoshioka, Hiroe</creatorcontrib><creatorcontrib>Kurosaki, Hiromu</creatorcontrib><creatorcontrib>Hirasawa, Miyuki</creatorcontrib><creatorcontrib>Uritani, Masahiro</creatorcontrib><creatorcontrib>Hasegawa, Kunihiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshinaga, Koichi</au><au>Yoshioka, Hiroe</au><au>Kurosaki, Hiromu</au><au>Hirasawa, Miyuki</au><au>Uritani, Masahiro</au><au>Hasegawa, Kunihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection by Trehalose of DNA from Radiation Damage</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>1997-01-01</date><risdate>1997</risdate><volume>61</volume><issue>1</issue><spage>160</spage><epage>161</epage><pages>160-161</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>The most serious damage to cells exposed to radiation is attributed mostly to effects on the structure of cellular DNA. We found that trehalose protects DNA from irradiation. In the presence of 10 mm trehalose, DNA can be protected from about 4 times higher doses of β- and γ-ray irradiation. The protective effect increases with the amount of the sugar. Other disaccharides, sucrose, and maltose had similar effects.</abstract><cop>Tokyo</cop><pub>Taylor & Francis</pub><pmid>9028044</pmid><doi>10.1271/bbb.61.160</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 1997-01, Vol.61 (1), p.160-161 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_proquest_journals_1449426372 |
| source | J-STAGE Free; MEDLINE; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Beta Particles Biological and medical sciences Biological effects of radiation DNA break DNA Damage - drug effects DNA Damage - radiation effects DNA, Circular - chemistry DNA, Circular - drug effects DNA, Circular - radiation effects DNA, Single-Stranded - chemistry DNA, Single-Stranded - drug effects DNA, Single-Stranded - radiation effects Dose-Response Relationship, Radiation Electrophoresis, Agar Gel Fundamental and applied biological sciences. Psychology Gamma Rays irradiation Maltose - pharmacology Radiation Protection - methods Radiation-Protective Agents - pharmacology radical scavenger Radioprotection Sensitivity and Specificity Sucrose - pharmacology Tissues, organs and organisms biophysics trehalose Trehalose - pharmacology tritium |
| title | Protection by Trehalose of DNA from Radiation Damage |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T05%3A01%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protection%20by%20Trehalose%20of%20DNA%20from%20Radiation%20Damage&rft.jtitle=Bioscience,%20biotechnology,%20and%20biochemistry&rft.au=Yoshinaga,%20Koichi&rft.date=1997-01-01&rft.volume=61&rft.issue=1&rft.spage=160&rft.epage=161&rft.pages=160-161&rft.issn=0916-8451&rft.eissn=1347-6947&rft_id=info:doi/10.1271/bbb.61.160&rft_dat=%3Cproquest_infor%3E16248187%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449426372&rft_id=info:pmid/9028044&rfr_iscdi=true |