Protection by Trehalose of DNA from Radiation Damage

Protection by Trehalose of DNA from Radiation Damage

The most serious damage to cells exposed to radiation is attributed mostly to effects on the structure of cellular DNA. We found that trehalose protects DNA from irradiation. In the presence of 10 mm trehalose, DNA can be protected from about 4 times higher doses of β- and γ-ray irradiation. The pro...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1997-01, Vol.61 (1), p.160-161
Hauptverfasser: Yoshinaga, Koichi, Yoshioka, Hiroe, Kurosaki, Hiromu, Hirasawa, Miyuki, Uritani, Masahiro, Hasegawa, Kunihiko
Format: Artikel
Sprache:eng
Schlagworte:
Beta Particles
Biological and medical sciences
Biological effects of radiation
DNA break
DNA Damage - drug effects
DNA Damage - radiation effects
DNA, Circular - chemistry
DNA, Circular - drug effects
DNA, Circular - radiation effects
DNA, Single-Stranded - chemistry
DNA, Single-Stranded - drug effects
DNA, Single-Stranded - radiation effects
Dose-Response Relationship, Radiation
Electrophoresis, Agar Gel
Fundamental and applied biological sciences. Psychology
Gamma Rays
irradiation
Maltose - pharmacology
Radiation Protection - methods
Radiation-Protective Agents - pharmacology
radical scavenger
Radioprotection
Sensitivity and Specificity
Sucrose - pharmacology
Tissues, organs and organisms biophysics
trehalose
Trehalose - pharmacology
tritium
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Zusammenfassung:The most serious damage to cells exposed to radiation is attributed mostly to effects on the structure of cellular DNA. We found that trehalose protects DNA from irradiation. In the presence of 10 mm trehalose, DNA can be protected from about 4 times higher doses of β- and γ-ray irradiation. The protective effect increases with the amount of the sugar. Other disaccharides, sucrose, and maltose had similar effects.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.61.160