Total Synthesis of (+)-Phrymarolin I from (+)-Malic Acid

(+)-Phrymarolin I was stereoselectively synthesized from (R)-(+)-3-hydroxybutanolide that had been prepared from (+)-malic acid. The procedure is more efficient than our previous synthesis in terms of fewer reaction steps and the easier availability of the starting material.

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1997, Vol.61 (4), p.660-663
Hauptverfasser: Okazaki, Momotoshi, Ishibashi, Fumito, Shuto, Yoshihiro, Taniguchi, Eiji
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container_issue 4
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container_title Bioscience, biotechnology, and biochemistry
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creator Okazaki, Momotoshi
Ishibashi, Fumito
Shuto, Yoshihiro
Taniguchi, Eiji
description (+)-Phrymarolin I was stereoselectively synthesized from (R)-(+)-3-hydroxybutanolide that had been prepared from (+)-malic acid. The procedure is more efficient than our previous synthesis in terms of fewer reaction steps and the easier availability of the starting material.
doi_str_mv 10.1271/bbb.61.660
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source Oxford University Press Journals All Titles (1996-Current); J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry
subjects (+)-phrymarolin I
(R)-(+)-3-hydroxybutanolide
Chemistry
Exact sciences and technology
furofuran lignan
Heterocyclic compounds
Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives
Organic chemistry
Preparations and properties
stereoselective synthesis
title Total Synthesis of (+)-Phrymarolin I from (+)-Malic Acid
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