Apoptosis to HL-60 by Humulone

Humulone, a bone resorption inhibitor isolated from hop extract, induced apoptosis in the premyocytic leukemia cell line HL-60 between 1 and 100 μg/ml. Our data suggested that there was a correlation between the apoptosis-inducing activity of humulone and its antioxidative activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1997, Vol.61 (6), p.1027-1029
Hauptverfasser:	Tobe, Hiroyasu, Kubota, Mitsuaki, Yamaguchi, Mitsune, Kocha, Tomoji, Aoyagi, Takaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - pharmacology Anticarcinogenic Agents - toxicity antioxidant Antioxidants - pharmacology apoptosis Apoptosis - drug effects Apoptosis - genetics Ascorbic Acid - pharmacology Biological and medical sciences Bone Resorption - prevention & control bone resorption inhibitor Cell Division - drug effects Cyclohexenes DNA Fragmentation - drug effects Dose-Response Relationship, Drug General pharmacology Genistein HL-60 HL-60 Cells - cytology HL-60 Cells - drug effects Humans humulone Isoflavones - pharmacology Lethal Dose 50 Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Quercetin - pharmacology Terpenes - pharmacology Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Humulone, a bone resorption inhibitor isolated from hop extract, induced apoptosis in the premyocytic leukemia cell line HL-60 between 1 and 100 μg/ml. Our data suggested that there was a correlation between the apoptosis-inducing activity of humulone and its antioxidative activity.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.61.1027