The Role of Cytochrome P-450sca in Streptomyces

The Role of Cytochrome P-450sca in Streptomyces

Azole compounds inhibited both hydroxylation catalyzed by cytochrome P-450sca and the growth of Streptomyces carbophilus. The growth inhibition could be overcome by inducing cytochrome P-450sca production in the cells. These results suggest that cytochrome P-450sca has an intrinsic substrate as well...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1993-10, Vol.57 (10), p.1777
Hauptverfasser: Serizawa, Nobufusa, Matsuoka, Tatsuji
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container_title Bioscience, biotechnology, and biochemistry
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creator Serizawa, Nobufusa
Matsuoka, Tatsuji
description Azole compounds inhibited both hydroxylation catalyzed by cytochrome P-450sca and the growth of Streptomyces carbophilus. The growth inhibition could be overcome by inducing cytochrome P-450sca production in the cells. These results suggest that cytochrome P-450sca has an intrinsic substrate as well as xenobiotics. Such a P-450 that has both substrates seems to be unique among the prokaryotic P-450 enzymes.
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title The Role of Cytochrome P-450sca in Streptomyces
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