The Role of Cytochrome P-450sca in Streptomyces
Azole compounds inhibited both hydroxylation catalyzed by cytochrome P-450sca and the growth of Streptomyces carbophilus. The growth inhibition could be overcome by inducing cytochrome P-450sca production in the cells. These results suggest that cytochrome P-450sca has an intrinsic substrate as well...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1993-10, Vol.57 (10), p.1777 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Azole compounds inhibited both hydroxylation catalyzed by cytochrome P-450sca and the growth of Streptomyces carbophilus. The growth inhibition could be overcome by inducing cytochrome P-450sca production in the cells. These results suggest that cytochrome P-450sca has an intrinsic substrate as well as xenobiotics. Such a P-450 that has both substrates seems to be unique among the prokaryotic P-450 enzymes. |
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| ISSN: | 0916-8451 1347-6947 |