Selective Methylation of Amines with Carbon Dioxide and H2

Selective Methylation of Amines with Carbon Dioxide and H2

Put a label on it: Carbon dioxide with H2 is shown to be an efficient and selective methylation reagent for aromatic and aliphatic amines (see scheme; acac=acetylacetonate, triphos = 1,1,1‐tris(diphenylphosphanylmethyl)ethane). A variety of functionalized amines including 13C‐labelled drugs were obt...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-11, Vol.52 (46), p.12156-12160
Hauptverfasser: Li, Yuehui, Sorribes, Iván, Yan, Tao, Junge, Kathrin, Beller, Matthias
Format: Artikel
Sprache:eng
Schlagworte:
homogeneous catalysis
hydrogen
methylation
reduction
ruthenium
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Beschreibung
Zusammenfassung:Put a label on it: Carbon dioxide with H2 is shown to be an efficient and selective methylation reagent for aromatic and aliphatic amines (see scheme; acac=acetylacetonate, triphos = 1,1,1‐tris(diphenylphosphanylmethyl)ethane). A variety of functionalized amines including 13C‐labelled drugs were obtained with good yields and functional‐group tolerance.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201306850